Isolation and characterization of a sigB deletion mutant of Staphylococcus aureus.
نویسندگان
چکیده
The sigB gene of Staphylococcus aureus, coding for the alternate sigma factor B, has been deleted by allelic replacement mutagenesis. The mutant grew as well as the parent in vitro, although it was deficient in clumping factor, coagulase, and pigment. In two murine and one rat infection model the mutant showed no reduction in virulence.
منابع مشابه
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عنوان ژورنال:
- Infection and immunity
دوره 67 7 شماره
صفحات -
تاریخ انتشار 1999